What to Expect During Spravato® (Esketamine) Treatment at Fuse Mind & Body

If you’ve tried multiple antidepressants without meaningful improvement, it’s normal to feel both hopeful and cautious about trying something new.

Spravato® (esktamine) therapy offers a different approach.

Unlike traditional medications that work primarily on serotonin, Spravato targets the brain’s glutamate system — helping restore neural connections and promoting faster relief for treatment-resistant depression.

Knowing what to expect ahead of time can make your first session feel more comfortable and predictable. While every person’s experience is unique, there are common effects most patients notice during treatment.

Here’s a clear, honest look at what a typical Spravato session at Fuse Mind & Body involves.

Your Treatment Environment

Spravato is administered in our medical office under the supervision of licensed healthcare providers.

This is not a take-home medication.

Every session is monitored for safety and comfort from start to finish.

You’ll relax in a quiet, private treatment room while our team checks your vitals and supports you throughout the process. Most patients bring headphones, calming music, or simply rest during the session.

Our goal is simple: a safe, calm, professionally supervised environment where you can focus on healing.

How Spravato Is Given

Spravato is delivered through a nasal spray device.

After administration, you’ll remain in the clinic for observation — typically about two hours — while the medication takes effect and gradually wears off.

Most people begin to notice changes in sensation within 15–30 minutes.

These effects are temporary and expected.

Common Experiences During Treatment

Not everyone feels the same things, but these are the most frequently reported effects.

Dissociation or “Detachment”

Many patients describe feeling mentally removed from their surroundings or observing their thoughts from a distance.

This can feel like:

• Floating

• Watching yourself from the outside

• Feeling mentally “lighter” or separated from stress

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While it may feel unusual at first, this state is normal — and often therapeutic.

This temporary shift can interrupt negative thought loops and give your brain space to reset. It’s one of the reasons ketamine-based treatments work differently than traditional antidepressants.

Altered Sense of Time or Space

Time may feel slower or faster than usual. Sessions might feel longer or shorter than they actually are.

This resolves naturally as the medication wears off.

Mood Changes or Emotional Release

Some patients feel:

• Calm

• Relief

• Lightness

• Emotional clarity

• Occasional euphoria

After living with depression, even brief positive shifts can feel meaningful. These moments often create space for deeper therapeutic progress, especially when paired with counseling or psychotherapy.

Visual or Sensory Changes

You may notice:

• Subtle visual distortions

• Changes in colors or light

• Dreamlike sensations

These are temporary and monitored by our team. They fade as the medication leaves your system.

Mild Side Effects

Some people experience:

• Nausea

• Dizziness

• Fatigue

• Temporary anxiety

These effects are usually mild and short-lived. Our providers are present the entire time to help manage anything that feels uncomfortable.

How Long Do Effects Last?

The noticeable effects typically last 1–2 hours.

After monitoring, most patients return home the same day feeling stable and clear-headed.

However, the therapeutic benefits often last much longer.

Many people report:

• Improvement within hours or days

• Reduced depressive symptoms

• Clearer thinking

• Less emotional heaviness

Benefits can continue between sessions as your brain forms healthier neural pathways.

Why Spravato Is Different

Spravato is:

• FDA-approved

• Clinically studied

• Administered only in medical settings

• Covered by most insurance plans

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Unlike IV ketamine infusions offered elsewhere, Spravato follows strict medical guidelines and insurance standards, which improves both safety and accessibility.

At Fuse, we also handle:

• Insurance verification

• Prior authorizations

• Billing coordination

So you’re not stuck fighting paperwork while trying to get better.

You focus on recovery. We handle the logistics.

How to Prepare for Your Appointment

A little preparation goes a long way.

Before your visit

• Get a good night’s sleep

• Avoid alcohol for 24 hours

• Eat lightly and avoid food 2 hours before treatment

• Arrange a ride home (no driving afterward)

• Wear comfortable clothing

During treatment

• Relax

• Listen to music or rest

• Communicate any concerns with our team

After treatment

• Take it easy

• Hydrate

• Rest

• Avoid major decisions or strenuous activity that day

Most patients prefer a quiet evening to let the experience settle.

Spravato Works Best as Part of a Bigger Plan

Medication is powerful — but long-term progress usually comes from combining treatment with therapy, lifestyle support, and consistent follow-up.

At Fuse Mind & Body, we look at the whole picture.

Our goal isn’t just symptom relief.

It’s real, lasting change.

Start Your Healing Journey at Fuse Mind & Body

If traditional antidepressants haven’t worked for you, Spravato may offer a new path forward.

Our team provides:

• FDA-approved Spravato treatment

• Medical supervision every session

• Insurance coordination

• A comfortable, supportive environment

• Personalized care plans

You don’t have to keep cycling through treatments that don’t help.

There is another option.

And you don’t have to navigate it alone.

Contact Fuse Mind & Body today to schedule a consultation and see if Spravato is right for you.